We are pleased to announce Mr. Ching-Ting Tsai’s lecture on July 7 (Fri.). Welcome to join us for the seminar on the nano-bio interface and bioelectronics. The speaker will share his research on the nanocrown electrode array (NcEA) for recording intracellular action potentials in cardiomyocytes and the NanoCurvS platform for analyzing curvature-sensitive proteins. These intelligent nano-tools have significant implications for drug development and understanding biological processes. Please find the lecture information attached and below:
Time: 2023/07/07 (Fri.) 11:00 -12:00
Venue: Rm212, Bldg. C, NBRP
Speaker: Ching-Ting Tsai (蔡京庭)
Moderator: Dr. Wen-Shan Li (李文山副主任)
Registration: https://forms.gle/Cfkudhyd8pBdyxcF7
Presentation Summary
The nano-bio interface is a rapidly evolving field that deals with nanomaterials interacting with and probing biological systems. Miniaturizing sensors to the nano- and micro-scales provides high-resolution measurements with minimal disruptions to biological systems. My research focuses on bioelectronics and the creation of intelligent nano-platforms for biological applications. The primary goal is to develop precise tools for investigating biological phenomena, such as electrical activity and protein dynamics.
In this presentation, I will share my research discoveries in bioelectronics and the quantitative curvature assay. I will introduce the nanocrown electrode array (NcEA) design, which enables accurate recording of intracellular action potentials in cardiomyocytes. This design overcomes previous limitations and serves as a valuable tool for assessing drug-induced arrhythmogenicity. Moving on to the quantitative curvature assay, I will discuss the NanoCurvS platform, an innovative creation that allows for precise analysis of curvature-sensitive proteins, particularly BAR family proteins. This platform effectively addresses challenges associated with probing low curvature regimes and provides quantitative information. By utilizing this platform, we have gained new insights into these curvature-sensitive proteins and their role in intracellular signaling.
Nanocrown electrode array (NcEA) and the NanoCurvS platform advance intelligent nano-tools for evaluating drug effects and investigating biological processes. These findings have the potential to impact diverse fields, ranging from drug development to understanding fundamental biological mechanisms.